Declinol, a Complex Containing Kudzu, Bitter Herbs Gentian, Tangerine Peeland Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test AUDIT Scores in Moderate to Heavy Drinkers: A Pilot Study

In fact our laboratory hypothesized that one such genetic factor that influences behavior including drug and food seeking is a predisposition to glucose craving and the overall effect of dopaminergic activity in the reward center of the brain. This defect drives individuals to engage in activities of behavioral excess, which will increase brain dopamine function, for which we created the term Reward Deficiency Syndrome to categorize such biological influences on behavior. Consuming large quantities of alcohol or carbohydrates stimulates the brain’s production and utilization of dopamine. So too does the intake of crack/cocaine and the abuse of nicotine.

  • In its raw form, kudzu root resembles other root tubers, such as potatoes or yams.
  • While the blood flow theory of kudzu for alcoholism may be true, there is likely more going on here.
  • It may seem counterintuitive that kudzu plant can work both as a hangover cure and to curb the desire to drink, but the same elements that help ease the physical consequences may push the body to feel alcohol’s effects sooner.
  • James Lake, M.D., a clinical assistant professor at the University of Arizona College of Medicine, works to transform mental health care through the evidence-based uses of alternative therapies.
  • Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD. Economic costs of excessive alcohol consumption in the U.S., 2006.

As an herbal plant extract, kudzu can be made available without a prescription. While it does not completely eliminate drinking, it is clearly effective in significantly reducing intake, which offers individuals an opportunity to engage in more responsible drinking patterns. As a safe, over-the-counter preparation, kudzu may be used alone in initial attempts to curb alcohol consumption, but it may also become a useful adjunct to the currently available prescription medications. This latter scenario might very well permit the use of lower doses of prescription medications and Sober House thus reduce the incidence of side effects. Furthermore, because kudzu extract exerts its beneficial effects within hours of the first dose, it could be administered along with a prescription medication and provide “coverage” until the other medication begins to work. The current evidence favors the safety of Kudzu root although some have questioned the potential build- up of acetaldehyde following its administration to humans . On the other side of the safety issue, Singh et al. evaluated the protective effects of puerarin from kudzu root against alcohol-induced toxicities.

Researchers Say Binge Drinkers Taking Kudzu Root Extract Drink Less

The responses to comments on fitrecovery.com are designed to support, not replace, medical or psychiatric treatment. Please seek professional care if you believe you may have a condition. Dr. Rebeca Eriksen is the Nutritional Consultant for Fit Recovery. She has a PhD in Nutritional Genetics from Imperial College London, and over ten years of clinical experience designing custom nutritional repair regimens for patients recovering from alcohol addiction. kudzu alcohol addiction In addition to her work at the exclusive Executive Health clinic in Marbella, Spain, she helps to keep Fit Recovery up to date with emerging research. My standards for categorizing an herb or drug as a “miracle” supplement are quite high. Something has to create a massive increase in sense of well-being to fit into this category. While kudzu does not quite make the cut, it is definitely worth trying if you’re looking to cut down on or quit drinking.

Dry heating of 6″-malonyl-7′-β-glucosyldaidzein leads to decarboxylation to 6″-acetyl-7′-β-glucosyldaidzein . Heated, aqueous extraction of soybeans to make soy milk and tofu, removes the malonyl group to make daidzin . Fermentation can also lead to hydrolysis of the glucosyl group . Daidzein and glycitein in soy and kudzu, and formononetin and biochanin A in red clover. Is one of the earliest medicinal plants used in traditional Chinese medicine. It has many profound pharmacological actions, including antidipsotropic activity. “We suspect it may work because it increases blood flow,” he says. “It may deliver alcohol to the brain’s reward center faster. So you get an effect sooner; therefore, you don’t drink as much.”

Natural Epigenetic-Modifying Molecules in Medical Therapy

Chris Scott founded Fit Recovery in 2014 to help people from around the world dominate alcohol dependence and rebuild their lives from scratch. A former investment banker, he recovered from alcohol dependence using cutting-edge methods that integrate nutrition, physiology, and behavioral change. Today, Chris is an Alcohol Recovery Coach and the creator of an online course called Total Alcohol Recovery 2.0. The last study above was designed to test the hypothesis that kudzu accelerates the subjective experience of alcohol intoxication. If this were the primary effect of kudzu increasing blood flow, then subjects should feel more intoxicated with fewer drinks after taking kudzu. Because of this effect, kudzu might also be helpful for people who have quit drinking and want to make sure that a potential slip doesn’t become a full blown relapse. Taking kudzu would decrease the chance that a drink would turn into an endless parade of drinks. Of course, it’s up to the individual to ensure that he or she doesn’t use this as an excuse to fall off the wagon.

Do Beekeepers live longer?

Beekeepers live longer than anybody else. Bees have been of human interest for over 5000 years due to the benefits of honey (Association 2005).

The anti-craving effect of disulfiram may also be due to inhibition of dopamine beta hydroxylase thereby increasing neuronal dopamine . “The fact that participants experienced a rapid rise in blood alcohol levels when pre-treated with kudzu has no apparent explanation and therefore requires additional research,” said Penetar. For the researchers, the next step is to determine if kudzu alters regional brain blood flow using an fMRI. Findings show that subjects who took kudzu drank an average of 1.8 beers per session, compared with the 3.5 beers consumed by those who took a placebo. Benlhabib E, Baker JI, Keyler DE, Singh AK. Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. Lukas and Lee hold a patent for kudzu extract to treat alcohol abuse and dependence.

“When they were treated with puerarin they drank about a beer less than when they were treated with placebo,” he says. Before the second, they took either 1,200 milligrams of puerarin or identical-looking placebo pills for a week. They came to the lab and could drink as much as they wanted, up to six beers. Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY. NPI-031G reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists.

“Recent research has found that several compounds of the isoflavone family – puerarin, daidzin, daidzein – in the kudzu extract decrease alcohol intake in experimental animals.” For targeting alcohol dependence, studies have used dosages of 1.2 grams of kudzu root extract per day over 1 week, or a single dose of 2 grams before drinking alcohol, without noted side effects . In some instances, even a single dose of kudzu extract reduced alcohol consumption and prevented binge drinking . Chinese medicine has used the kudzu plant for centuries to treat stiff neck, sprains, thirst and diarrhea, and to reduce drinking.

Medication for Cravings in Substance Use Disorders

This pretreatment time was selected based on our pharmacokinetic study of puerarin absorption and elimination (Penetar et al., 2006). During the baseline session, the placebo-randomized group consumed 2.7 ± 0.78 beers before treatment and increased consumption to 3.4 ± 1.1 beers after treatment. The kudzu group significantly reduced consumption from 3.0 ± 1.7 at baseline to 1.9 ± 1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment.

When alcohol is consumed, kudzu may reduce the time it takes for it to travel to the brain. A slightly increased concentration of alcohol in the brain results in a quicker reward, which in turn reduces a person’s desire to drink more alcohol. In one study, people who binge drink took either kudzu extract or a placebo before a 90-minute session of drinking beer. The researchers observed 12 men and women in a double-blind placebo-controlled study. The participants were either treated with kudzu or a placebo for nine days, and then received a medium or high alcohol challenge to determine how prominently they presented alcohol-related symptoms. David M. Penetar, senior author of the study and assistant Professor of Psychology in the Department of Psychiatry at McLean Hospital, said that kudzu has been around for centuries to treat alcohol intoxication, hangovers and other related problems in humans. One possibility is through the different isoflavones, which are biologically active molecules that can affect physiology, contained within the kudzu extract.

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Because my drinking levels were so stupendously high in the first place, kudzu did not turn me into a moderate drinker by any stretch of the imagination. As expected, I didn’t really feel anything after taking kudzu until I began drinking. I recall feeling a very slight prickly feeling in my skin after I’d had a few drinks, and a mild head rush. I did not feel more drunk than usual, but I definitely drank less. Overall, my drinking during that month declined by around 30-40%. Thus, I’m going to make sure I cover all of these topics and more so you become very knowledgeable about how kudzu works for helping people get better from alcoholism. Ashwagandha is an herbal supplement made from the Withania somnifera plant. A 2017 research review found that acupuncture helped with alcohol cravings and withdrawal.
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Alcohol withdrawal after 70 days of drinking generated severe withdrawal symptoms including seizure-type EEG activity. Puerarin suppressed the addictionmediated abnormalities but did not affect the inflammation-related abnormalities. There are many ways, both medical and traditional, that are used to treat alcohol abuse or dependence. In China, kudzu root extract has been commonly used to reduce, but not eliminate, alcohol consumption and dependence. Despite its history, the mechanism of action for kudzu extract is still unknown, and that is what the current research explores.

Dietary soy isoflavones occur bound to sugars that are not readily absorbed and may be modified extensively in the gastrointestinal tract, although the degree of metabolism and absorption varies considerably among individuals. In daidzin , the link between daidzein and glucose is a COC bond, whereas in puerarin , it is a CC bond. Isoflavones are structurally similar to 17β-estradiol and have been the subject of intense research regarding their effects on human health as agonists of the ERβ receptor. Whereas the B-ring in flavones is in the 2-position (e.g., apigenin, A), for isoflavones it is in the 3-position (e.g., genistein, B). Though there have been limited clinical trials of the single use of Gegen, it can be a potential candidate to suppress aging-related neuronal cell apoptosis and dysfunction of the memory system. The plant Cytisus laburnum from which cytisine is derived is traditionally used as an emetic and purgative, so nausea and vomiting is the main side effect. Like verenicline, it can disrupt the sleep cycle and cause nightmares.

A synthetic form of daidzin, called CVT-10216, can successfully reduce drinking and prevent relapse in preclinical rodent models. The study showed that subjects taking puerarin drank significantly fewer beers—dropping from 3.5 beers on average to 2.4. It’s best to speak with your healthcare provider to determine whether kudzu root could interact with any medications you’re taking. For instance, it may reduce the effectiveness of birth control due to its estrogenic effects . People often eat different parts of the plant raw, sautéed, deep-fried, baked, or jellied.
kudzu alcohol addiction
The compound puerarin is always found in the highest concentration among all the isoflavones, second is daidzin, followed by daidzein. A small study showed that in heavy drinkers of alcohol, kudzu did result in a reduction of the number of beers consumed after 7 days of treatment. Drinking was recorded using a custom built end table that contained a digital scale beneath a ceramic tile insert in the tabletop (Ohaus model #B10P with I5S controller). Participants were instructed to always keep the beer glass on the table except when taking a sip. The scale was connected to a computer in an adjacent room that ran a customized program that sampled the scale at 5 Hz and detected any weight changes that exceeded 1 gm. Additional details and photos of the device can be found in Lukas et al. . Participants were randomized on a blind basis to receive either 4 capsules of the extract or placebo 2.5 hours before the start of an afternoon drinking session.
kudzu alcohol addiction

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